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Our laboratory focuses on understanding the biology of cancer progression and drug resistance, the development of green nanotechnology-based drug formulations and drug delivery systems, the mechanistic details of drug action in cancer cells, and nanoparticle-mediated radiosensitization of cancer cells. In these investigations, we use a combination of cellular and biophysical experiments, super-resolution microscopy, and computer-assisted simulations.

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Green nanotechnology-based drug formulations and drug-delivery systems: Over the past couple of decades, nano-formulation of existing anticancer drugs and other natural product molecules has emerged as a potential therapeutic strategy to enhance the efficacy and target-specific delivery of anti-cancer drugs. We are focusing on the development of green nanotechnology-assisted nano-formulations of natural product molecules, their mechanisms of action, efficacy, potential as radiosensitizers, and target specificity.

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Non-apoptotic cell death mechanisms: One of the prevalent features of cancer cells is their resistance to natural or drug-induced apoptosis. Although several alternate cell death mechanisms have been identified, the biology of these non-apoptotic cell death mechanisms is not yet fully comprehended. Understanding the molecular details of these mechanisms would help identify potential inducers that can kill cancer cells that are resistant to apoptosis.